|
Congenital absence of kidneys syndrome
|
0.400 |
GermlineCausalMutation
|
disease |
ORPHANET |
FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man.
|
22698282 |
2012 |
|
RENAL HYPODYSPLASIA/APLASIA 2
|
0.400 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Parkinson Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These include FGF3 in Michel aplasia; FGF8 in cleft lip/palate and in hypogonadotropic hypogonadism; FGF9 in carcinoma; FGF10 in the lacrimal/salivary glands aplasia, and lacrimo-auriculo-dento-digital syndrome; FGF14 in spinocerebellar ataxia; FGF20 in Parkinson disease; and FGF23 in tumoral calcinosis and hypophosphatemic rickets.
|
19621416 |
2009 |
|
Parkinson Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In silico interrogation of the Broad Institute's Connectivity Map database (CMap), revealed 50 candidate drugs predicted to increase FGF20 transcription, 16 of which had profiles favourable for use in Parkinson's disease.
|
31171821 |
2019 |
|
Colorectal Neoplasms
|
0.020 |
AlteredExpression
|
group |
LHGDN |
Molecular cloning and characterization of human FGF-20 on chromosome 8p21.3-p22.
|
10913340 |
2000 |
|
Malignant tumor of colon
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
FGF-20 mRNA of 2.4 kb in size was detected in colon cancer cell line SW480 by Northern blot analysis.
|
10913340 |
2000 |
|
Inflammatory Bowel Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
FGF-20, having demonstrated therapeutic activity in 2 experimental models of intestinal inflammation, represents a promising new candidate for the treatment of human inflammatory bowel disease.
|
12360478 |
2002 |
|
Ataxia, Spinocerebellar
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These include FGF3 in Michel aplasia; FGF8 in cleft lip/palate and in hypogonadotropic hypogonadism; FGF9 in carcinoma; FGF10 in the lacrimal/salivary glands aplasia, and lacrimo-auriculo-dento-digital syndrome; FGF14 in spinocerebellar ataxia; FGF20 in Parkinson disease; and FGF23 in tumoral calcinosis and hypophosphatemic rickets.
|
19621416 |
2009 |
|
Parkinsonian Disorders
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Our study is the first to uncover the potential link between manganese exposure, altered miRNA expression and parkinsonism: manganese exposure causes overexpression of SNCA and FGF-20 by diminishing miR-7 and miR-433 levels.
|
28986288 |
2018 |
|
Colon Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
FGF-20 mRNA of 2.4 kb in size was detected in colon cancer cell line SW480 by Northern blot analysis.
|
10913340 |
2000 |
|
Hypophosphatemic Rickets
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These include FGF3 in Michel aplasia; FGF8 in cleft lip/palate and in hypogonadotropic hypogonadism; FGF9 in carcinoma; FGF10 in the lacrimal/salivary glands aplasia, and lacrimo-auriculo-dento-digital syndrome; FGF14 in spinocerebellar ataxia; FGF20 in Parkinson disease; and FGF23 in tumoral calcinosis and hypophosphatemic rickets.
|
19621416 |
2009 |
|
Familial Hypophosphatemic Rickets
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These include FGF3 in Michel aplasia; FGF8 in cleft lip/palate and in hypogonadotropic hypogonadism; FGF9 in carcinoma; FGF10 in the lacrimal/salivary glands aplasia, and lacrimo-auriculo-dento-digital syndrome; FGF14 in spinocerebellar ataxia; FGF20 in Parkinson disease; and FGF23 in tumoral calcinosis and hypophosphatemic rickets.
|
19621416 |
2009 |
|
Congenital absence of kidneys syndrome
|
0.400 |
Biomarker
|
disease |
HPO |
|
|
|
|
RENAL HYPODYSPLASIA/APLASIA 2
|
0.400 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man.
|
22698282 |
2012 |
|
RENAL HYPODYSPLASIA/APLASIA 2
|
0.400 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man.
|
22698282 |
2012 |
|
Bipolar Disorder
|
0.300 |
Biomarker
|
disease |
PSYGENET |
Molecular genetics and developmental studies have identified 21 genes in this region (ADRA1A, ARHGEF10, CHRNA2, CHRNA6, CHRNB3, DKK4, DPYSL2, EGR3, FGF17, FGF20, FGFR1, FZD3, LDL, NAT2, NEF3, NRG1, PCM1, PLAT, PPP3CC, SFRP1 and VMAT1/SLC18A1) that are most likely to contribute to neuropsychiatric disorders (schizophrenia, autism, bipolar disorder and depression), neurodegenerative disorders (Parkinson's and Alzheimer's disease) and cancer.
|
19204725 |
2009 |
|
Mental Depression
|
0.300 |
Biomarker
|
disease |
PSYGENET |
Molecular genetics and developmental studies have identified 21 genes in this region (ADRA1A, ARHGEF10, CHRNA2, CHRNA6, CHRNB3, DKK4, DPYSL2, EGR3, FGF17, FGF20, FGFR1, FZD3, LDL, NAT2, NEF3, NRG1, PCM1, PLAT, PPP3CC, SFRP1 and VMAT1/SLC18A1) that are most likely to contribute to neuropsychiatric disorders (schizophrenia, autism, bipolar disorder and depression), neurodegenerative disorders (Parkinson's and Alzheimer's disease) and cancer.
|
19204725 |
2009 |
|
Depressive disorder
|
0.300 |
Biomarker
|
disease |
PSYGENET |
Molecular genetics and developmental studies have identified 21 genes in this region (ADRA1A, ARHGEF10, CHRNA2, CHRNA6, CHRNB3, DKK4, DPYSL2, EGR3, FGF17, FGF20, FGFR1, FZD3, LDL, NAT2, NEF3, NRG1, PCM1, PLAT, PPP3CC, SFRP1 and VMAT1/SLC18A1) that are most likely to contribute to neuropsychiatric disorders (schizophrenia, autism, bipolar disorder and depression), neurodegenerative disorders (Parkinson's and Alzheimer's disease) and cancer.
|
19204725 |
2009 |
|
Cleft Palate
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Orbital separation excessive
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Previous studies have demonstrated that FGF20 enhances the survival of dopaminergic neurons suggesting the potential use of FGF20 to treat Parkinson's disease (PD).
|
30043675 |
2018 |
|
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that the FGF20 gene is a susceptibility gene for Parkinson's disease in the Japanese population.
|
17515805 |
2007 |
|
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
LHGDN |
We also replicated the association of fibroblast growth factor 20 (FGF20) with PD (P = 0.0089).
|
18568448 |
2008 |
|
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results suggest that FGF 20 is a susceptibility gene for PD in Eastern Indians.
|
29604408 |
2018 |
|
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
In a cell-based system and in PD brains, this increase in translation of FGF20 is correlated with increased alpha-synuclein expression, which has previously been shown to cause PD through both overexpression and point mutations.
|
18252210 |
2008 |